Structure of PDB 4wa7 Chain A

Receptor sequence
>4wa7A (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVP
MVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLV
REIRKHK
3D structure
PDB4wa7 Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
ChainA
Resolution1.986 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 D30 N116 K117 D119 L120 S145 A146 K147 G14 V15 G16 K17 S18 A19 F29 D31 N106 K107 D109 L110 S135 A136 K137
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wa7, PDBe:4wa7, PDBj:4wa7
PDBsum4wa7
PubMed26037647
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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