Structure of PDB 4wa5 Chain A

Receptor sequence
>4wa5A (length=388) Species: 1136533 (Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))) [Search protein sequence]
QFMQNTEALCDVKGFAPFSKDNGIRIGSRGHVFVIREPFVSCSPTECRTF
FLTQGSLLNDKHSNGTEKDRSPYRTLMSVEIGQSPNVYQARFEAVAWSAT
ACHDGKKWMTIGVTGPDAKAVAVVHYGGIPTDVINSWAGDILRTQESSCT
CILGECYWVMTDGPANRQAQYRAFKAKQGKIIGQVEISFNGGHIEECSCY
PNDGKVECVCRDNWTGTNRPVLVISPDLSYRVGYLCAGLSSDTPRGEDSQ
FTGSCTSPVGNQGYGVKGFGFRQGNDVWMGRTISRTSRSGFEILKVRNGW
VQTSKEQIKRQVVVDNLNRSGYSGSFTLPVELTKRDCLVPCFWVEMIRGK
PAEKTIWTSSSSIVMCGVDHEVADWSWHDGAILPFDID
3D structure
PDB4wa5 Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 E276 R291 R368 Y402
Catalytic site (residue number reindexed from 1) D69 E196 R211 R288 Y322
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZMR A R116 E117 R150 W177 R223 E226 E275 R291 R368 Y402 R36 E37 R70 W97 R143 E146 E195 R211 R288 Y322 MOAD: ic50=1.29nM
BS02 CA A D292 G296 D322 G343 Y344 D212 G216 D242 G263 Y264
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wa5, PDBe:4wa5, PDBj:4wa5
PDBsum4wa5
PubMed25540377
UniProtI6NW33

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