Structure of PDB 4wa4 Chain A

Receptor sequence
>4wa4A (length=384) Species: 1136533 (Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))) [Search protein sequence]
QFMQNTEALCDVKGFAPFSKDNGIRIGSRGHVFVIREPFVSCSPTECRTF
FLTQGSLLNDKHSNGRSPYRTLMSVEIGQSPNVYQARFEAVAWSATACHD
GKKWMTIGVTGPDAKAVAVVHYGGIPTDVINSWAGDILRTQESSCTCILG
ECYWVMTDGPANRQAQYRAFKAKQGKIIGQVEISFNGGHIEECSCYPNDG
KVECVCRDNWTGTNRPVLVISPDLSYRVGYLCAGLSSDTPRGEDSQFTGS
CTSPVGNQGYGVKGFGFRQGNDVWMGRTISRTSRSGFEILKVRNGWVQTS
KEQIKRQVVVDNLNRSGYSGSFTLPVELTKRDCLVPCFWVEMIRGKPAEK
TIWTSSSSIVMCGVDHEVADWSWHDGAILPFDID
3D structure
PDB4wa4 Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E276 R291 R368 Y402
Catalytic site (residue number reindexed from 1) E192 R207 R284 Y318
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G39 A R116 E117 R150 E275 R291 Y344 R368 Y402 R36 E37 R66 E191 R207 Y260 R284 Y318 MOAD: ic50=0.66nM
BS02 CA A D292 G296 D322 Y344 D208 G212 D238 Y260
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wa4, PDBe:4wa4, PDBj:4wa4
PDBsum4wa4
PubMed25540377
UniProtI6NW33

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