Structure of PDB 4w9x Chain A

Receptor sequence
>4w9xA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
VGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPD
LNVCKREITIMKELSGHKNIVGYLDCAVNSISWEVLILMEYCRAGQVVNQ
MNKKQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGG
NYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKP
ITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHC
LIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALPEPMT
3D structure
PDB4w9x Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
ChainA
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D180 K182 N185 D198 N208 T226
Catalytic site (residue number reindexed from 1) D138 K140 N143 D156 N166 T184
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JW A A58 E59 G60 S63 A77 V109 M130 C133 Q137 E184 N185 L187 D198 A20 E21 G22 S25 A39 V71 M89 C92 Q96 E142 N143 L145 D156 PDBbind-CN: -logKd/Ki=7.40,Kd=39.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4w9x, PDBe:4w9x, PDBj:4w9x
PDBsum4w9x
PubMed26853940
UniProtQ9NSY1|BMP2K_HUMAN BMP-2-inducible protein kinase (Gene Name=BMP2K)

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