Structure of PDB 4w9w Chain A

Receptor sequence
>4w9wA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
VGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPD
LNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQV
VNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILL
NDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLY
GGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSR
NIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALP
EPMTAS
3D structure
PDB4w9w Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D180 K182 N185 D198 N208 T226
Catalytic site (residue number reindexed from 1) D142 K144 N147 D160 N170 T188
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YDJ A A77 Y132 C133 G136 N185 L187 C197 A39 Y94 C95 G98 N147 L149 C159 PDBbind-CN: -logKd/Ki=7.48,Kd=33.1nM
BS02 YDJ A N289 Y313 F314 F318 N251 Y275 F276 F280 PDBbind-CN: -logKd/Ki=7.48,Kd=33.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4w9w, PDBe:4w9w, PDBj:4w9w
PDBsum4w9w
PubMed26853940
UniProtQ9NSY1|BMP2K_HUMAN BMP-2-inducible protein kinase (Gene Name=BMP2K)

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