Structure of PDB 4w9s Chain A

Receptor sequence
>4w9sA (length=200) Species: 387207 (Influenza A virus (A/duck/Hokkaido/8/1980(H3N8))) [Search protein sequence]
GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVC
FMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSIC
NTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHI
HIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB4w9s Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H46 D113 E124 I125
BS02 MN A E80 D108 E85 D113
BS03 3K1 A K34 A37 I38 H41 E80 D108 E119 K134 K39 A42 I43 H46 E85 D113 E124 K139 MOAD: ic50=0.15uM
PDBbind-CN: -logKd/Ki=6.82,IC50=0.15uM
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4w9s, PDBe:4w9s, PDBj:4w9s
PDBsum4w9s
PubMed25225968
UniProtP13166|PA_I80A6 Polymerase acidic protein (Gene Name=PA)

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