Structure of PDB 4w9o Chain A

Receptor sequence
>4w9oA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
TVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKK
FDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSA
GSLPKIPSNATLFFEIELLDFKG
3D structure
PDB4w9o Rational Design and Asymmetric Synthesis of Potent and Neurotrophic Ligands for FK506-Binding Proteins (FKBPs).
ChainA
Resolution1.27 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1) Y41 F51 D52 I71 Y97 F114
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JQ A Y57 F67 D68 F77 G84 Q85 V86 I87 W90 Y113 S118 F130 Y41 F51 D52 F61 G68 Q69 V70 I71 W74 Y97 S102 F114 PDBbind-CN: -logKd/Ki=7.77,Ki=17nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4w9o, PDBe:4w9o, PDBj:4w9o
PDBsum4w9o
PubMed25412894
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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