Structure of PDB 4w8y Chain A

Receptor sequence
>4w8yA (length=835) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
MVNIKEKLFVYLHDPPDKALKIENHEERSKKILSSGNIQDKVKQADALSS
KTQRFIIREPVIDFLGRFHVGYPVFIHPISTEIKRYETLEKYIDLGRSNR
GERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFYPVKL
KEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTSAL
SVKDPTLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVDKF
GPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAEKI
EEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVRE
YFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERI
AIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDH
DNLKSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNW
RKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGLSIDEEK
VKEVVDFLNAAYKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHP
NIRDYVEIPEAKYYSTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGG
DDVLAILPVDKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYKHP
LYDALEKARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFY
NSELRKKLLERFIYHVLREVDTWPIDEMLKFEVIRHIKEETKELREKIYG
EIKDLLEHVRGNNEVEKVRGLFTFLKIITDAEVFP
3D structure
PDB4w8y Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C448 C451 C478 C481 C434 C437 C464 C467
BS02 MN A D14 H25 D14 H25
BS03 MN A H13 D14 D50 H207 H13 D14 D46 H193
BS04 MN A D600 D673 D674 D578 D651 D652
BS05 MN A E656 E694 E700 E634 E672 E678
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4w8y, PDBe:4w8y, PDBj:4w8y
PDBsum4w8y
PubMed25280103
UniProtQ8U1S6|CMR2_PYRFU CRISPR system Cmr subunit Cmr2 (Gene Name=cmr2)

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