Structure of PDB 4w5s Chain A

Receptor sequence
>4w5sA (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
AGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKV
VNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAY
IGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCR
VTLGKSFLQFSTMKMAHAPPGHHSVIGRPSALAYAEYVIYRGEQAYPEYL
ITYQIMKPE
3D structure
PDB4w5s Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3J1 A H1184 G1185 Y1203 Y1213 A1215 K1220 S1221 Y1224 H81 G82 Y100 Y110 A112 K117 S118 Y121
BS02 ZN A C1234 H1237 C1242 C1245 C131 H134 C139 C142
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4w5s, PDBe:4w5s, PDBj:4w5s
PDBsum4w5s
PubMed25815142
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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