Structure of PDB 4w5a Chain A

Receptor sequence
>4w5aA (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSMGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDIS
RDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRRELSTIMDEN
NQWYCYICHPEPLLDLVTACNSVYENLE
3D structure
PDB4w5a ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y43 D48 M56 E58 A64 E65 G66 G67 N68 L69 C71 D73 Y43 D48 M56 E58 A64 E65 G66 G67 N68 L69 C71 D73
BS02 ZN A C11 C14 C37 C40 C11 C14 C37 C40
BS03 ZN A C60 C63 C80 C83 C60 C63 C80 C83
BS04 ZN A C72 C75 C105 C72 C75 C105
External links
PDB RCSB:4w5a, PDBe:4w5a, PDBj:4w5a
PDBsum4w5a
PubMed25538301
UniProtP46100|ATRX_HUMAN Transcriptional regulator ATRX (Gene Name=ATRX)

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