Structure of PDB 4w50 Chain A

Receptor sequence
>4w50A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
GNEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVME
PSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYY
ESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLS
KKGFYLAFQDVGACIALVSVRVFYKKA
3D structure
PDB4w50 Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I59 Q71 C73 T104 R106 P112 R162 M164 C191 I32 Q44 C46 T77 R79 P85 R135 M137 C164
BS02 BU2 A E30 K202 E3 K175
External links
PDB RCSB:4w50, PDBe:4w50, PDBj:4w50
PDBsum4w50
PubMed25268696
UniProtP54764|EPHA4_HUMAN Ephrin type-A receptor 4 (Gene Name=EPHA4)

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