Structure of PDB 4w4v Chain A

Receptor sequence
>4w4vA (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK
LSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYL
VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENV
DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV
RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP
AKRISVDDALQHPYINVWYDQLDEREHTIEEWKELIYKEVMN
3D structure
PDB4w4v Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
ChainA
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D145 K147 N150 D163 T182
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3H8 A I70 G73 Q75 V78 A91 K93 I124 L144 M146 L148 M149 D150 A151 L206 I26 G29 Q31 V34 A47 K49 I80 L100 M102 L104 M105 D106 A107 L162 MOAD: ic50=866nM
PDBbind-CN: -logKd/Ki=6.94,IC50=115nM
BindingDB: IC50=866nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4w4v, PDBe:4w4v, PDBj:4w4v
PDBsum4w4v
PubMed25623238
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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