Structure of PDB 4v8v Chain A

Receptor sequence

>4v8vA (length=2822) Species: 1773 (Mycobacterium tuberculosis)

AHALVDRLSAGEPYAVAFGGQGSAWLETLEELVSSAGIESELATLAGEAE
LLLEPVASELVVVRPIGFEPLQWVRALAAEEPVPSDKQLTSAAVSVPGVL
LTQIAAVRALARQGMDLTATPPVAVAGHSQGVLAVQALAAKGAKDVELLA
LAQLIGAAGTLVARRRGITVLGDRPPMVSVTNADPERIYELLEEFSSDVR
TVLPPVLSIRNGRRSVVITGTPEQLSRFELYCTQIAEKEEAERKNKLRGG
AVFAPVFDPVQVEVGFHTPRLSDGIEIVGRWAETVGLDVELAKELTESIL
VRQVDWVDEITELHEAGARWILDLGPGDILTRLTAPVIRGLGIGIVPAAT
RGGQRNLFTVGAVPEVARPWSSYAPTVVKLPDGSVKLETKFTRLTGRSPI
LLAGMTPTTVDAKIVAAAANAGHWAELAGGGQVTEQIFNDRIAELETLLE
PGRAIQFNTLFLDPYLWKLQVGGKRLVQRARQSGAPIDGLVVSAGIPDLE
EAVDIIDELNEVGISHVVFKPGTVEQIRSVIRIAAEVPTKPVIVHIEGGR
AGGHHSWEDLDDLLLATYSELRSRSNITICVGGGIGTPERSAEYLSGRWA
EVHGYPLMPIDGILVGTAAMATLEATTSPQVKQLLVETKGTEAWVGAGKA
ANGMASGRSQLGADIHEIDNAASRCGRLLDEVAGDADAVAERRDEIIAAM
AQTAKPYFGDVAEMTYLQWLRRYVELAIGDGNSTADTKRPDSPWLDITWR
DRFEQMLKRAEARLHPQDFGPIETLFDADADGERLLEDPEAAITALLQRY
PDAETVVLHPADVPFFVELCKTLGKPVNFVPVIDKDVRRWWRSDSLWQAH
DARYEADQVCVIPGTAAVAGITRVDEPVGELLDRFEQAAVDEVLGAGAEP
VEVLSRRQARRDASGPLAVVLDAPDVLWAGRMSVNPVHRIAAPTEWQVRE
GSDNRSASHPSTGARLEVADDQHVVLSVPLSGTWIEIRFTLTDVVRSGGA
PIVEVDDAATAMRAVLAIAAGVEGPENLPKVVDNTATVTVDWDPERVADH
TGVTATFGAPLAPTLTVVPDALVGRCWPAVFAAIGSAATEAGFPVIEGLL
SLVHLDHAARLLAELPKEPAEFTVTAKASAATDTEVGRVVPVSVEVRNAA
DGALLATLEERFAIRGRTGAAELTDPVRAGGAISDNATDTPRRRRRDVTV
GAPVDMRPFAVVSGDHNPIHTDRAAALLAGLEGPIVHGMWLSAAAQHVVT
ATDGKPVPPAKLIGWTARFLGMVKPGDQVDFRVDRVGIDVGAEVLEVSAR
IGSELVMAATARLAAPKTVYAFPGQGIQHKGMGMEVRARSKAARKVWDSA
DKFTRETLGFSVLHVVRDNPTSLIASGVHYHHPDGVLFLTQFTQVAMATV
AAAQVAEMREQGAFVEGAIACGHSVGEYTALACVSGVYELEALLEVVFHR
GSKMHDIVPRDELGRSNYRLAAIRPSQIDLDDADVKDFVAEISERTGEFL
EIVNFNLRGSQYAIAGTVAGLEALEEEIERRRQITGGKRSFILVPGIDVP
FHSSVLRVGVADFRRSLERVMPRDKDPELIIGRYIPNLVPRPFTLDRDFI
QEIRDLVPAEPLDEVLADYDTWRNEKPKELCRKVVIELLAWQFASPVRWI
ETQDLLFIEEAAGGLGVERFVEIGVKSAPTVAGLATNTLKLPEYSHSTVE
VLNSERDAAVLFATDSAALGEFAEKVTGPDGVLASAARLVLNQLGLSDVV
TTPEAATDAELIDLVTAELGSDWPRLVAPTFDARKAVVFDDRWASAREDL
VKLWLAEEGDIDAQWEQLSQRFEGTGHVVATQANWWQGKALAAGRNVHAS
LFGRIAAGAENPGKGRYSDEVAVVTGASKGSIAASVVGQLLDGGATVIAT
TSRLDDDRLAFYKQLYRDHARFDATLWVVPANMASYSDIDKLVEWVGTEQ
TESLGPQSIHLKDAQTPTLLFPFAAPRVAGDMSEVGSRAEMEMKVLLWAV
QRLISGLSKIGAERDIASRLHVVLPGSPNRGMFGGDGAYGEAKSALDALE
NRWSAEKSWAERVSLAHALIGWTKGTGLMGQNDAIVSAVEEAGVTTYTTD
EMAAMLLDLCTVETKVAAAGAPVKVDLTGGLGDIKIDMAELAAKAREEMS
GAADESDDEAPAGTIRALPSPPRGYNPAPAPEWDDLDVDPADLVVIVGGA
ELGPYGSSRTRFEMEVSGELSAAGVLELAWTTGMVKWEDDPKAGWYDTET
GELVPECEIVERYHDAVVERCGIREFVDDGAIDPDHASPLLVSVFLDKDF
TFVVSSEADARAFVQFDPEHTVARPLPDSSDWEVTRKAGTEIRVPRKTKL
SRTVGAQIPTGFDPTVWGISPDMASSIDRVALWNIVATVDAFLSSGFTPT
ELMRWVHPSQVASTQGTGMGGMTSMQTMYHGNLLGRAKPNDILQEVLPNV
VAAHVMQSYVGGYGAMVHPVGACATAAVSVEEGVDKIKLGKADLVIAGGF
DDLTLEAIIGFGDMAATADTEMMRAKGISDSKFSRANDRRRLGFLEAQGG
GTILLARGDLALKMGLPVLAVVGYAQSFADGVHTSIPAPGLGALGAARGG
RESTLARSLAQLGVGADDIAVISKHDTSTLANDPNETELHERIADSMGRA
PGNPLFIVSQKTLTGHAKGGAAVFQMMGLCQILRDGVIPPNRSLDCVDDE
LATSGHFVWVREPLDLRGKFPLKAGLVTSLGFGHVSGLVALVHPEAFIAA
LDPSEREDYRTRAEQRMLAGQRRLVSAIAGGRPMYEKPADRRFDHDVPEK
RQEAAMLLSTDARLGENDQYVL

3D structure

• PDB: 4v8v Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex.
• Chain: A
• Resolution: 20.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FMN	A	G434 M435 T436 P437 L490 S523 K550 E577 A581 G613 G614 G646 T647 I892	G404 M405 T406 P407 L460 S493 K520 E547 A551 G583 G584 G616 T617 I862

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Nov 24 17:20:57 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '4v8v', asym_id = 'A', title = 'Structure and Conformational Variability of the ...rculosis Fatty Acid Synthase Multienzyme Complex.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='4v8v', asym_id='A', title='Structure and Conformational Variability of the ...rculosis Fatty Acid Synthase Multienzyme Complex.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004312,0004318,0005835,0006633,0016740,0016746', uniprot = '', pdbid = '4v8v', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004312,0004318,0005835,0006633,0016740,0016746', uniprot='', pdbid='4v8v', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>