Structure of PDB 4v0i Chain A

Receptor sequence
>4v0iA (length=759) Species: 10090 (Mus musculus) [Search protein sequence]
KKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGW
VEWLQYSFPLQLEPVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACA
LRKKATVQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMV
HSSSILAMRDEQSNQPFSIELIVQAGLFHGNEMLCKTDISVCDLPRMARL
CFALYADCPIAWANLMLFDYKDQLKTGERCLYMWPSLLNPAGTVRGNPNT
ESAAALVIYLPEVAPVYFPALEKILELEHEKDLVWKMRHEVQEHFPEALA
RLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAI
KSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFL
FWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALND
FVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVE
QCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLM
DVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLTAAFNKDA
LLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES
GQLFHIDFGHFLGPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTIL
RRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRV
KFNEALRES
3D structure
PDB4v0i Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications.
ChainA
Resolution2.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J82 A F751 M752 P758 W760 I777 Y813 E826 V827 V828 M900 I910 D911 F504 M505 P511 W513 I530 Y566 E579 V580 V581 M646 I656 D657 PDBbind-CN: -logKd/Ki=6.33,IC50=468nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4v0i, PDBe:4v0i, PDBj:4v0i
PDBsum4v0i
PubMed27144736
UniProtO35904|PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Gene Name=Pik3cd)

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