Structure of PDB 4v0h Chain A

Receptor sequence
>4v0hA (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
TEPLCGASPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQGA
EAALEEAARGPILVDTGGPWAREALLGALAGQGVAPGDVTLVVGTHGHSD
HIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGPGLEVWATPG
HGGQRDVSVVVAGTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRK
RVLVVADVVVPGHGPPFRVL
3D structure
PDB4v0h Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H117 H119 H122 H172 D195 H96 H98 H101 H151 D174
BS02 FE A D121 H122 D195 H234 D100 H101 D174 H213
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008334 histone mRNA metabolic process
GO:0031124 mRNA 3'-end processing
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:4v0h, PDBe:4v0h, PDBj:4v0h
PDBsum4v0h
PubMed30507380
UniProtA4D2B0|MBLC1_HUMAN Metallo-beta-lactamase domain-containing protein 1 (Gene Name=MBLAC1)

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