Structure of PDB 4v01 Chain A

Receptor sequence
>4v01A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEDPRWELPRDRLVLGKPLGGQVVLAEAIGLDKPNRVTKVAVKMLKSDA
TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
EYLQARRPPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED
NVMKIADFIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWE
IFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS
QRPTFKQLVEDLDRIVALTSNQE
3D structure
PDB4v01 Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4
ChainA
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 A625 R627 N628 D641
Catalytic site (residue number reindexed from 1) D139 A141 R143 N144 D157
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A A512 K514 E531 M534 M535 I545 V561 Y563 A564 I620 H621 L630 I639 A640 D641 A42 K44 E61 M64 M65 I75 V91 Y93 A94 I136 H137 L146 I155 A156 D157 PDBbind-CN: -logKd/Ki=8.11,Kd=7.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4v01, PDBe:4v01, PDBj:4v01
PDBsum4v01
PubMed25465127
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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