Structure of PDB 4uyh Chain A

Receptor sequence
>4uyhA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMG
TIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL
QKVASMPQE
3D structure
PDB4uyh The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9S3 A W97 P98 K107 L108 N156 I162 W23 P24 K33 L34 N82 I88 MOAD: ic50=0.00000001M
PDBbind-CN: -logKd/Ki=6.30,IC50=0.50uM
BindingDB: IC50=501nM
External links
PDB RCSB:4uyh, PDBe:4uyh, PDBj:4uyh
PDBsum4uyh
PubMed25249180
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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