Structure of PDB 4uye Chain A

Receptor sequence
>4uyeA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTM
KQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAV
LRQARRQAE
3D structure
PDB4uye 1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9F9 A I652 F653 E655 V657 P658 E661 N708 F714 I24 F25 E27 V29 P30 E33 N80 F86 MOAD: Kd=9.54nM
PDBbind-CN: -logKd/Ki=8.02,Kd=9.54nM
BindingDB: IC50=79nM
External links
PDB RCSB:4uye, PDBe:4uye, PDBj:4uye
PDBsum4uye
PubMed25408830
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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