Structure of PDB 4uyd Chain A

Receptor sequence
>4uydA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4uyd 1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain.
ChainA
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V1T A P82 L92 N140 I146 P40 L50 N98 I104 MOAD: ic50=79.4uM
PDBbind-CN: -logKd/Ki=4.10,IC50=79.43uM
BindingDB: IC50=79433nM
External links
PDB RCSB:4uyd, PDBe:4uyd, PDBj:4uyd
PDBsum4uyd
PubMed25408830
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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