Structure of PDB 4uy6 Chain A

Receptor sequence
>4uy6A (length=321) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
TLSLANYLAADSAAEALRRDVRAGLTAAPKSLPPKWFYDAVGSDLFDQIT
RLPEYYPTRTEAQILRTRSAEIIAAAGADTLVELGSGTSEKTRMLLDAMR
DAELLRRFIPFDVDAGVLRSAGAAIGAEYPGIEIDAVCGDFEEHLGKIPH
VGRRLVVFLGSTIGNLTPAPRAEFLSTLADTLQPGDSLLLGTDLVKDTGR
LVRAYDDAAGVTAAFNRNVLAVVNRELSADFDLDAFEHVAKWNSDEERIE
MWLRARTAQHVRVAALDLEVDFAAGEEMLTEVSCKFRPENVVAELAEAGL
RQTHWWTDPAGDFGLSLAVRL
3D structure
PDB4uy6 Structural Insights Into the Histidine Trimethylation Activity of Egtd from Mycobacterium Smegmatis.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.44: L-histidine N(alpha)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HIS A Y56 N166 Y206 E282 Y55 N165 Y205 E281
BS02 SAH A Y39 F47 G86 S87 G88 K92 D113 V114 G140 D141 F142 Y38 F46 G85 S86 G87 K91 D112 V113 G139 D140 F141
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0052706 L-histidine N(alpha)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:4uy6, PDBe:4uy6, PDBj:4uy6
PDBsum4uy6
PubMed25251321
UniProtA0R5M8|EGTD_MYCS2 Histidine N-alpha-methyltransferase (Gene Name=egtD)

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