Structure of PDB 4uxl Chain A

Receptor sequence
>4uxlA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
IENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLK
KGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGD
LLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAAR
NCLVSVKDYTSPRIVKIGDFGLARDIYKEGLLPVRWMAPESLMDGIFTTQ
SDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLW
NLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKS
3D structure
PDB4uxl Pf-06463922 is a Potent and Selective Next-Generation Ros1/Alk Inhibitor Capable of Blocking Crizotinib-Resistant Ros1 Mutations.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D2079 A2081 R2083 N2084 D2102 E2120
Catalytic site (residue number reindexed from 1) D146 A148 R150 N151 D169 E179
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5P8 A L1951 A1978 L2026 M2029 G2032 L2086 G2101 K2228 S2229 L18 A45 L93 M96 G99 L153 G168 K287 S288 MOAD: Ki<0.025nM
PDBbind-CN: -logKd/Ki=10.60,Ki<0.025nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4uxl, PDBe:4uxl, PDBj:4uxl
PDBsum4uxl
PubMed25733882
UniProtP08922|ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (Gene Name=ROS1)

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