Structure of PDB 4uxh Chain A

Receptor sequence
>4uxhA (length=173) Species: 5664 (Leishmania major) [Search protein sequence]
RGRIELIIGPMFAGKTTELMRRVKREIHARRSCFVIKYSKDTRYDEHNVA
LMLRAQAAVSQLTEVRDTWKRFDVLAIDEGQFFSDLVDFCNTAADAGKVV
MVSALDGDYRRKPFGQICELVPYCEAVDKLTAVCMMCHEQPACFTRRTVN
VEQQELIGGADMYIATCRECYSK
3D structure
PDB4uxh Structural and Kinetic Characterization of Thymidine Kinase from Leishmania Major.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T5A A M13 F14 G16 K17 T18 T19 M22 K39 Y46 E85 Q87 F88 L111 D114 Y115 F120 T151 Q160 L162 G164 Y169 M11 F12 G14 K15 T16 T17 M20 K37 Y44 E79 Q81 F82 L105 D108 Y109 F114 T145 Q154 L156 G158 Y163 MOAD: ic50=1.1uM
PDBbind-CN: -logKd/Ki=5.96,IC50=1.1uM
BS02 ZN A C140 C143 C173 C176 C134 C137 C167 C170
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4uxh, PDBe:4uxh, PDBj:4uxh
PDBsum4uxh
PubMed25978379
UniProtQ4QC75

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