Structure of PDB 4ux8 Chain A

Receptor sequence
>4ux8A (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWIRIQEDTGLLYLQRSLDHSSWEKLSVRNRGFPLLTVYLKVFLS
PCQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTF
HQFRLLPVQFLCPQISVAYRLLEGEGLPFRSAPDSLEVSTRWALDREQRE
KYELVAVCTVHREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRK
EDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNET
SVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSLHLPSTYSL
SVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAED
TSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSY
3D structure
PDB4ux8 Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association.
ChainA
Resolution24.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E178 D264 E265 D267 D302 E143 D226 E227 D229 D264
BS02 CA A E178 D230 R231 E232 D267 E143 D195 R196 E197 D229
BS03 CA A D266 S268 D300 D302 G308 R360 D228 S230 D262 D264 G270 R322
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ux8, PDBe:4ux8, PDBj:4ux8
PDBsum4ux8
PubMed25242331
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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