Structure of PDB 4uwg Chain A

Receptor sequence
>4uwgA (length=544) Species: 9606 (Homo sapiens) [Search protein sequence]
LKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLK
CVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLR
QADDEDLLMYLLQLVQALKYENFDDIKNGLEAEIDSSQIITSPLPLEQDL
CTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFS
QALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQA
LLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKT
EDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLAT
STKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTY
VKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPP
PMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVD
ANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHA
3D structure
PDB4uwg Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxobutyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RBQ A F612 P618 I634 Y670 M682 Q683 F684 I685 L750 I760 F287 P293 I309 Y345 M357 Q358 F359 I360 L425 I435 PDBbind-CN: -logKd/Ki=8.15,IC50=7nM
BindingDB: IC50=7.0nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4uwg, PDBe:4uwg, PDBj:4uwg
PDBsum4uwg
PubMed25402320
UniProtQ8NEB9|PK3C3_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (Gene Name=PIK3C3)

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