Structure of PDB 4uuq Chain A

Receptor sequence
>4uuqA (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
SPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHS
GRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVD
SMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPES
ATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGL
KVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAK
SQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTA
3D structure
PDB4uuq Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents.
ChainA
Resolution2.36 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.1.23: acylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 64D A S132 M133 L158 N162 S165 L215 G220 L223 L224 C252 S117 M118 L143 N147 S150 L200 G205 L208 L209 C237 PDBbind-CN: -logKd/Ki=7.54,IC50=29nM
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0047372 monoacylglycerol lipase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006639 acylglycerol metabolic process
GO:0006954 inflammatory response
GO:0009966 regulation of signal transduction
GO:0016042 lipid catabolic process
GO:0019369 arachidonate metabolic process
GO:0019433 triglyceride catabolic process
GO:0046464 acylglycerol catabolic process
GO:0050727 regulation of inflammatory response
GO:0051930 regulation of sensory perception of pain
GO:0052651 monoacylglycerol catabolic process
GO:2000124 regulation of endocannabinoid signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4uuq, PDBe:4uuq, PDBj:4uuq
PDBsum4uuq
PubMed25560837
UniProtQ99685|MGLL_HUMAN Monoglyceride lipase (Gene Name=MGLL)

[Back to BioLiP]