Structure of PDB 4utw Chain A

Receptor sequence
>4utwA (length=229) Species: 195102 (Clostridium perfringens str. 13) [Search protein sequence]
GSHHHHHHHMLDVVKGNLIVSCQALSDEPLHSSFIMGRMAIAAKQGGAAA
IRAQGVNDINEIKEVTKLPIIGIIKRNYDDSEIYITPTMKEVDELLKTDC
EMIALDATKRKRPNGENVKDLVDAIHAKGRLAMADISTLEEGIEAEKLGF
DCVSTTLSGYTPYSKQSNSVDFELLEELVKTVKIPVICEGRINTPEELKK
ALDLGAYSAVVGGAITRPQQITKRFTDIL
3D structure
PDB4utw Structural and Functional Characterization of the Clostridium Perfringens N-Acetylmannosamine-6-Phosphate 2-Epimerase Essential for the Sialic Acid Salvage Pathway
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.1.3.9: N-acylglucosamine-6-phosphate 2-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RFW A R43 K66 Y75 T147 Y151 E180 R182 G203 R52 K75 Y84 T156 Y160 E189 R191 G212
Gene Ontology
Molecular Function
GO:0016853 isomerase activity
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0047465 N-acylglucosamine-6-phosphate 2-epimerase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006051 N-acetylmannosamine metabolic process
GO:0006053 N-acetylmannosamine catabolic process
GO:0019262 N-acetylneuraminate catabolic process
Cellular Component
GO:0005829 cytosol

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External links
PDB RCSB:4utw, PDBe:4utw, PDBj:4utw
PDBsum4utw
PubMed25320079
UniProtQ8XNZ3|NANE_CLOPE Putative N-acetylmannosamine-6-phosphate 2-epimerase (Gene Name=nanE)

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