Structure of PDB 4usw Chain A

Receptor sequence
>4uswA (length=458) Species: 9606 (Homo sapiens) [Search protein sequence]
MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISG
FTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDA
LLALWRVERKQLKNIITVVIKCSLEIHGLFLDIRVKIGLAAGHISMLVFG
DETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVP
DQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPD
PELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAE
EIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFGEKVPDEL
THALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQ
KVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGPL
YQYWGRTE
3D structure
PDB4usw Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A D47 S49 G50 T52 A97 G98 D99 F338 L345 V406 N412 D47 S49 G50 T52 A97 G98 D99 F330 L337 V397 N403 MOAD: Kd=2.03mM
PDBbind-CN: -logKd/Ki=2.69,Kd=2.03mM
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:4usw, PDBe:4usw, PDBj:4usw
PDBsum4usw
PubMed25040695
UniProtQ96PN6|ADCYA_HUMAN Adenylate cyclase type 10 (Gene Name=ADCY10)

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