Structure of PDB 4uro Chain A

Receptor sequence
>4uroA (length=187) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
EAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDN
WIKVTDNGRGIPVDIQEKMGRPAVEVILTVGVGSSVVNALSQDLEVYVHR
NETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYET
LQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG
3D structure
PDB4uro Structures of Kibdelomycin Bound to Staphylococcus Aureus Gyrb and Pare Showed a Novel U-Shaped Binding Mode.
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NOV A N54 S55 E58 D81 R84 I86 P87 D89 I102 R144 N29 S30 E33 D56 R59 I61 P62 D64 I77 R100 PDBbind-CN: -logKd/Ki=8.40,IC50<4nM
BindingDB: IC50=41nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4uro, PDBe:4uro, PDBj:4uro
PDBsum4uro
PubMed24992706
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

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