Structure of PDB 4uqv Chain A

Receptor sequence
>4uqvA (length=426) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MEYSDVPKFIRDVSIKQHEWMRESIKLIASENITSLAVREACATDFMHRY
AEGLPLYQGCKYIDEVETLCIELSKELFKAEHANVQPTSGVVANLAVFFA
ETKPGDKLMALSVPDGGHISHWKVSAAGIRGLKVINHPFDPEEMNIDADA
MVKKILEEKPKLILFGGSLFPFPHPVADAYEAAQEVGAKIAYDGAHVLGL
IAGKQFQDPLREGAEYLMGSTHKTFFGPQGGVILTTKENADKIDSHVFPG
VVSNHHLHHKAGLAIALAEMLEFGEAYAKQVIKNAKALAQALYERGFNVL
CEHKDFTESHQVIIDIESSPDIEFSASELAKMYEEANIILNKNLLPWDDV
NNSDNPSGIRLGTQECTRLGMKEKEMEEIAEFMKRIAIDKEKPEKVREDV
KEFAKEYSTIHYSFDEGDGFKYLRFY
3D structure
PDB4uqv The Crystal Structure of Archaeal Serine Hydroxymethyltransferase Reveals Idiosyncratic Features Likely Required to Withstand High Temperatures.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y50 E52 D196 S223 K226 Q232
Catalytic site (residue number reindexed from 1) Y50 E52 D193 S220 K223 Q229
Enzyme Commision number 2.1.2.-
4.1.2.49: L-allo-threonine aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A S92 G93 V94 H124 D196 A198 S223 H225 K226 S89 G90 V91 H121 D193 A195 S220 H222 K223
BS02 PLP A S256 N257 S253 N254
Gene Ontology
Molecular Function
GO:0004372 glycine hydroxymethyltransferase activity
GO:0008732 L-allo-threonine aldolase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006545 glycine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008652 amino acid biosynthetic process
GO:0019264 glycine biosynthetic process from serine
GO:0035999 tetrahydrofolate interconversion
GO:0046653 tetrahydrofolate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4uqv, PDBe:4uqv, PDBj:4uqv
PDBsum4uqv
PubMed25257552
UniProtQ58992|GLYA_METJA Serine hydroxymethyltransferase (Gene Name=glyA)

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