Structure of PDB 4uox Chain A

Receptor sequence
>4uoxA (length=453) Species: 562 (Escherichia coli) [Search protein sequence]
SASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKS
VTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSA
VQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEA
ALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRKPFMPLLPG
FRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPPPGYLTA
VRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGV
MPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLP
AQAEQKGDMLLDGFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFAS
EMFRQRVLVAGTLNNAKTIRIEPPLTLTIEQCELVIKAARKALAAMRVSV
EEA
3D structure
PDB4uox Structure of Putrescine Aminotransferase from Escherichia Coli Provides Insights Into the Substrate Specificity Among Class III Aminotransferases.
ChainA
Resolution2.085 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F50 F180 E238 D271 Q274 K300 T332 R426
Catalytic site (residue number reindexed from 1) F44 F174 E232 D265 Q268 K294 T326 R420
Enzyme Commision number 2.6.1.29: diamine transaminase.
2.6.1.82: putrescine--2-oxoglutarate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A S149 G150 T151 F180 H181 G182 D271 V273 Q274 S143 G144 T145 F174 H175 G176 D265 V267 Q268
BS02 PUT A E243 K300 E237 K294
BS03 PLP A T331 T332 T325 T326
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0019161 diamine transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0033094 putrescine--2-oxoglutarate transaminase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0009447 putrescine catabolic process
GO:0019477 L-lysine catabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4uox, PDBe:4uox, PDBj:4uox
PDBsum4uox
PubMed25423189
UniProtP42588|PAT_ECOLI Putrescine aminotransferase (Gene Name=patA)

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