Structure of PDB 4uoe Chain A

Receptor sequence
>4uoeA (length=281) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KKWFSEFSIMWPGQAFSLKIKKILYETKSKYQNVLVFESTTYGKVLVLDG
VIQLTEKDEFAYHEMMTHVPMTVSKEPKNVLVVGGGDGGIIRELCKYKSV
ENIDICEIDETVIEVSKIYFKNISCGYEDKRVNVFIEDASKFLENVTNTY
DVIIVDSSDPIGPAETLFNQNFYEKIYNALKPNGYCVAQCESLWIHVGTI
KNMIGYAKKLFKKVEYANISIPTYPCGCIGILCCSKTDTGLTKPNKKLES
KEFADLKYYNYENHSAAFKLPAFLLKEIENI
3D structure
PDB4uoe Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA A G124 G125 D127 E147 I148 V152 D178 A179 D196 S198 P203 A204 G84 G85 D87 E107 I108 V112 D138 A139 D156 S158 P163 A164
BS02 4ZY A Y102 D196 S197 D199 Y264 Y62 D156 S157 D159 Y224
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4uoe, PDBe:4uoe, PDBj:4uoe
PDBsum4uoe
PubMed25760598
UniProtQ8II73

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