Structure of PDB 4unc Chain A

Receptor sequence

>4uncA (length=181) [Search protein sequence]

VSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITQKSENLIKQHIAPLM
QFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNMREQ
IAFIKGLYVAEGDKTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHLDDH
RHGVYVLNISLRDRIKFVHTILSSHLNPLPP

3D structure

PDB

4unc Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	D21 T41 Q42 K43 T76 R77 R124 T150 H152 D154 R157 S166 L167	D15 T35 Q36 K37 T70 R71 R118 T144 H146 D148 R151 S160 L161
BS02	dna	A	N32 R33 S34 E35 Y36 R37 S67 K68 R81 S83 S84 K85 E117 W128 N129 K130 D155 H158 V160	N26 R27 S28 E29 Y30 R31 S61 K62 R75 S77 S78 K79 E111 W122 N123 K124 D149 H152 V154
BS03	dna	A	G20 D21 G22 Y25 Y29 R33 R37 R77	G14 D15 G16 Y19 Y23 R27 R31 R71
BS04	dna	A	A116 D119 K120 R124 R126 W128	A110 D113 K114 R118 R120 W122
BS05	dna	A	K86 Y89 N93	K80 Y83 N87
BS06	MN	A	D21 A116	D15 A110
BS07	MN	A	G20 E117	G14 E111
BS08	MN	A	D21 E117	D15 E111

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0016539	intein-mediated protein splicing

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4unc, PDBe:4unc, PDBj:4unc
PDBsum	4unc
PubMed	25486305
UniProt	P21505\|DMO1_DESMO Homing endonuclease I-DmoI

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