Structure of PDB 4un8 Chain A

Receptor sequence

>4un8A (length=184) [Search protein sequence]

NENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITQKSENLIKQHIA
PLMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNM
REQIAFIKGLYVAEGDKTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHL
DDHRHGVYVLNISLRDRIKFVHTILSSHLNPLPP

3D structure

PDB

4un8 Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	G20 D21 G22 Y25 Y29 R33 R37 T41 K43 T76 R77 E117 R124 T150 H152 D154 R157 S166 L167	G17 D18 G19 Y22 Y26 R30 R34 T38 K40 T73 R74 E114 R121 T147 H149 D151 R154 S163 L164
BS02	dna	A	G31 N32 R33 S34 E35 Y36 R37 S67 K68 Q70 R81 S83 S84 K85 A116 E117 G118 D119 K120 R124 R126 W128 N129 K130 D155 H158 V160	G28 N29 R30 S31 E32 Y33 R34 S64 K65 Q67 R78 S80 S81 K82 A113 E114 G115 D116 K117 R121 R123 W125 N126 K127 D152 H155 V157
BS03	dna	A	K86 Y89 N93	K83 Y86 N90
BS04	MN	A	D21 A116	D18 A113
BS05	MN	A	G20 E117	G17 E114

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0016539	intein-mediated protein splicing

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4un8, PDBe:4un8, PDBj:4un8
PDBsum	4un8
PubMed	25486305
UniProt	P21505\|DMO1_DESMO Homing endonuclease I-DmoI

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