Structure of PDB 4un7 Chain A

Receptor sequence

>4un7A (length=184) [Search protein sequence]

NENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITQKSENLIKQHIA
PLMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNM
REQIAFIKGLYVAEGDKTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHL
DDHRHGVYVLNISLRDRIKFVHTILSSHLNPLPP

3D structure

PDB

4un7 Visualizing Phosphodiester-Bond Hydrolysis by an Endonuclease.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	D21 G22 Y25 Y29 R33 R37 T41 Q42 K43 T76 R77 R124 T150 H152 D154 R157 N164 S166 L167	D18 G19 Y22 Y26 R30 R34 T38 Q39 K40 T73 R74 R121 T147 H149 D151 R154 N161 S163 L164
BS02	dna	A	N32 R33 S34 E35 Y36 R37 S67 K68 Q70 R77 R81 S83 S84 K85 E117 D119 R124 R126 W128 N129 K130 D155 H158 V160	N29 R30 S31 E32 Y33 R34 S64 K65 Q67 R74 R78 S80 S81 K82 E114 D116 R121 R123 W125 N126 K127 D152 H155 V157
BS03	dna	A	K86 Y89 N93	K83 Y86 N90
BS04	ZN	A	D21 A116	D18 A113

Gene Ontology

	Molecular Function
GO:0004519	endonuclease activity

	Biological Process
GO:0006314	intron homing
GO:0016539	intein-mediated protein splicing

View graph for
Molecular Function

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Biological Process

External links

PDB	RCSB:4un7, PDBe:4un7, PDBj:4un7
PDBsum	4un7
PubMed	25486305
UniProt	P21505\|DMO1_DESMO Homing endonuclease I-DmoI

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