Structure of PDB 4umw Chain A

Receptor sequence
>4umwA (length=603) Species: 624 (Shigella sonnei) [Search protein sequence]
RLKENLPLITLIVMMAISWGLEQFNHPFGQLAFIATTLVGLYPIARQALR
LIKSGSYFAIETLMSVAAIGALFIGATAEAAMVLLLFLIGERLEGWAASR
VSALMALKPETATRLRNGEREEVAINSLRPGDVIEVAAGGRLPADGKLLS
PFASFDESALTGESIPVERATGDKVPAGATSVDRLVTLEVLSEPGASAID
RILKLIEEAEERRAPIERFIDRFSRIYTPAIMAVALLVTLVPPLLFAASW
QEWIYKGLTLLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQL
GRVTQVAFDKTGTLTVGKPRVTAIHPATGISESELLTLAAAVEQGATHPL
AQAIVREAQVAELAIPTAESQRALVGSGIEAQVNGERVLICAAGKHPADA
FAGLINELESAGQTVVLVVRNDDVLGIIALQDTLRADAATAISELNALGV
KGVILTGDNPRAAAAIAGELGLEFKAGLLPEDKVKAVTKLNQHAPLAMVG
DGINDAPAMKAAAIGIAMGSGTDVALETADAALTHNHLRGLVQMIELARA
THANIRQNITIALGLKGIFLVTTLLGMTGLWLAVLADTGATVLVTANALR
LLR
3D structure
PDB4umw Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases.
ChainA
Resolution2.705 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D436 D628 D632
Catalytic site (residue number reindexed from 1) D309 D501 D505
Enzyme Commision number 7.2.2.-
7.2.2.12: P-type Zn(2+) transporter.
7.2.2.21: Cd(2+)-exporting ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A G289 D436 K437 T438 T583 K610 G162 D309 K310 T311 T456 K483
BS02 MG A D436 D628 D309 D501
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0008551 P-type cadmium transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015662 P-type ion transporter activity
GO:0016463 P-type zinc transporter activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4umw, PDBe:4umw, PDBj:4umw
PDBsum4umw
PubMed25132545
UniProtQ3YW59|ZNTA_SHISS Zinc/cadmium/lead-transporting P-type ATPase (Gene Name=zntA)

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