Structure of PDB 4umv Chain A

Receptor sequence
>4umvA (length=605) Species: 624 (Shigella sonnei) [Search protein sequence]
KENLPLITLIVMMAISWGLEQFNHPFGQLAFIATTLVGLYPIARQALRLI
KSGSYFAIETLMSVAAIGALFIGATAEAAMVLLLFLIGERLEGWAASRAR
QGVSALMALKPETATRLRNGEREEVAINSLRPGDVIEVAAGGRLPADGKL
LSPFASFDESALTGESIPVERATGDKVPAGATSVDRLVTLEVLSEPGASA
IDRILKLIEEAEERRAPIERFIDRFSRIYTPAIMAVALLVTLVPPLLFAA
SWQEWIYKGLTLLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALE
QLGRVTQVAFDKTGTLTVGKPRVTAIHPATGISESELLTLAAAVEQGATH
PLAQAIVREAQVAELAIPTAESQRALVGSGIEAQVNGERVLICAAGKHPA
DAFAGLINELESAGQTVVLVVRNDDVLGIIALQDTLRADAATAISELNAL
GVKGVILTGDNPRAAAAIAGELGLEFKAGLLPEDKVKAVTKLNQHAPLAM
VGDGINDAPAMKAAAIGIAMGSGTDVALETADAALTHNHLRGLVQMIELA
RATHANIRQNITIALGLKGIFLVTTLLGMTGLWLAVLADTGATVLVTANA
LRLLR
3D structure
PDB4umv Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D436 D628 D632
Catalytic site (residue number reindexed from 1) D311 D503 D507
Enzyme Commision number 7.2.2.-
7.2.2.12: P-type Zn(2+) transporter.
7.2.2.21: Cd(2+)-exporting ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T438 D628 T313 D503
BS02 BEF A G289 D436 T438 D628 N631 G164 D311 T313 D503 N506
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0008551 P-type cadmium transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015662 P-type ion transporter activity
GO:0016463 P-type zinc transporter activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4umv, PDBe:4umv, PDBj:4umv
PDBsum4umv
PubMed25132545
UniProtQ3YW59|ZNTA_SHISS Zinc/cadmium/lead-transporting P-type ATPase (Gene Name=zntA)

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