Structure of PDB 4umj Chain A

Receptor sequence
>4umjA (length=269) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
IAAYQARCQARVDAALDALFVAPREELQRLYEAMRYSVMNGGKRVRPLLA
YAACEALGGAPQRADAAACAVELIHAYSLVHDDLPAMDDDDLRRGQPTTH
RAFDEATAILAADGLQALAFEVLADTRRNPQEHAVCLEMLTRLARAAGSA
GMVGGQAIDLGSLDQAALEVMHRHKTGALIEASVRLGALASGRAEPASLA
ALERYAEAIGLAFQVQDDILDVPTYPALLGLEAAKGYALELRDLALAALD
GFPPSADPLRQLARYIVER
3D structure
PDB4umj Structural Characterization of Substrate and Inhibitor Binding to Farnesyl Pyrophosphate Synthase from Pseudomonas Aeruginosa.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D83 D89 D82 D88
BS02 MG A D83 D89 D82 D88
BS03 BFQ A S79 D83 R94 M153 Q157 K180 S78 D82 R93 M152 Q156 K175 MOAD: ic50=2.7uM
PDBbind-CN: -logKd/Ki=5.57,IC50=2.7uM
BS04 BFQ A F218 D222 F213 D217 MOAD: ic50=2.7uM
PDBbind-CN: -logKd/Ki=5.57,IC50=2.7uM
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4umj, PDBe:4umj, PDBj:4umj
PDBsum4umj
PubMed25760619
UniProtQ9HWY4

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