Structure of PDB 4uiz Chain A

Receptor sequence
>4uizA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4uiz The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
ChainA
Resolution1.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N1D A W81 P82 L92 L94 Y139 N140 W40 P41 L51 L53 Y98 N99 MOAD: ic50=0.00001995M
PDBbind-CN: -logKd/Ki=4.70,IC50=19.95uM
External links
PDB RCSB:4uiz, PDBe:4uiz, PDBj:4uiz
PDBsum4uiz
PubMed25856009
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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