Structure of PDB 4uiy Chain A

Receptor sequence
>4uiyA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4uiy The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5V2 A W81 P82 V87 L92 N140 K141 D144 I146 W40 P41 V46 L51 N99 K100 D103 I105 MOAD: ic50=0.00000001M
PDBbind-CN: -logKd/Ki=5.60,IC50=2.51uM
External links
PDB RCSB:4uiy, PDBe:4uiy, PDBj:4uiy
PDBsum4uiy
PubMed25856009
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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