Structure of PDB 4uiu Chain A

Receptor sequence
>4uiuA (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
STPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMK
DKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMM
S
3D structure
PDB4uiu The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TVU A F44 F45 V49 I53 Y99 N100 R101 T104 Y106 F23 F24 V28 I32 Y78 N79 R80 T83 Y85 MOAD: ic50=0.00000001M
PDBbind-CN: -logKd/Ki=7.90,IC50=12.6nM
External links
PDB RCSB:4uiu, PDBe:4uiu, PDBj:4uiu
PDBsum4uiu
PubMed25856009
UniProtQ9H8M2|BRD9_HUMAN Bromodomain-containing protein 9 (Gene Name=BRD9)

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