Structure of PDB 4uee Chain A

Receptor sequence
>4ueeA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
RSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLK
FSTGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILD
TLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGF
GLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQL
LMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQAS
GSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIM
EHTLNHP
3D structure
PDB4uee Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
ChainA
Resolution2.27 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H68 E71 R126 H195 E269
Enzyme Commision number 3.4.17.1: carboxypeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LA9 A H69 E72 R127 N144 R145 H196 Y198 I243 Y248 T268 E270 H68 E71 R126 N143 R144 H195 Y197 I242 Y247 T267 E269 BindingDB: Ki=0.140000nM
BS02 ZN A H69 E72 H196 H68 E71 H195
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4uee, PDBe:4uee, PDBj:4uee
PDBsum4uee
PubMed
UniProtP15085|CBPA1_HUMAN Carboxypeptidase A1 (Gene Name=CPA1)

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