Structure of PDB 4udb Chain A

Receptor sequence
>4udbA (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SPVMVLENIEPEIVYAGYDPDTAENLLSTLNRLAGKQMIQVVKWAKVLPG
FKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLVFNEEK
MHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQ
AAFEEMRTNYIKELRKMVTKSPNNSGQSWQRFYQLTKLLDSMHDLVSDLL
EFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHR
3D structure
PDB4udb Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I802 M959 E962 V42 K46 L56 I63 M220 E223
BS02 CV7 A L766 L769 N770 A773 Q776 M807 L810 F829 M845 M852 F941 C942 T945 L27 L30 N31 A34 Q37 M68 L71 F90 M106 M113 F202 C203 T206 MOAD: Ki=0.18nM
PDBbind-CN: -logKd/Ki=9.15,IC50=0.7nM
External links
PDB RCSB:4udb, PDBe:4udb, PDBj:4udb
PDBsum4udb
PubMed26602186
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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