Structure of PDB 4uda Chain A

Receptor sequence
>4udaA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
PVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVL
PGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKHTNSQFLYFAPDLVFNE
EKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLK
SQAAFEEMRTNYIKELRKMVTKSGQSWQRFYQLTKLLDSMHDLVSDLLEF
CFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHR
3D structure
PDB4uda Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 A958 M959 E962 V44 K48 L58 I62 A217 M218 E221
BS02 DEX A L769 N770 A773 Q776 M807 S810 F829 M845 F941 C942 T945 L32 N33 A36 Q39 M70 S73 F92 M108 F200 C201 T204 MOAD: Ki=6.3nM
PDBbind-CN: -logKd/Ki=7.59,IC50=26.0nM
BindingDB: IC50=33nM,Ki=7.2nM
External links
PDB RCSB:4uda, PDBe:4uda, PDBj:4uda
PDBsum4uda
PubMed26602186
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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