Structure of PDB 4ud7 Chain A

Receptor sequence
>4ud7A (length=97) Species: 9606 (Homo sapiens) [Search protein sequence]
GSSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTK
RLYDAAQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB4ud7 Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M50 L54 F55 G58 I61 M62 Y67 Q72 H73 V93 H96 Y100 Y104 M36 L40 F41 G44 I47 M48 Y53 Q58 H59 V79 H82 Y86 Y90
BS02 peptide A G15 Q18 G1 Q4
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4ud7, PDBe:4ud7, PDBj:4ud7
PDBsum4ud7
PubMed27532490
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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