Structure of PDB 4uci Chain A

Receptor sequence

>4uciA (length=361) Species: 162145 (human metapneumovirus) [Search protein sequence]

DPTEQLAYFPKITFERLKNGKLTRNYMILLPWQHVNRYNFVFSSTGCKVS
LKTCIGKLMKDLNPKVLYFIGEGAGNWMARTACEYPDIKFVYRSLKDDLD
HHYPLEYQRVIGELSRIIDSGEGLSMETTDATQKTHWDLIHRVSKDALLI
TLCDAEFKDRDDFFKMVILWRKHVLSCRICTTYGTDLYLFAKYHAKDCNV
KLPFFVRSVATFIMQGSKLSGSECYILLTLGHHNNLPCHGEIQNSKMKIA
VCNDFYAAKKLDNKSIEANCKSLLSGLRIPINKKELNRQRRLLTKWLTNK
ANTIIDWLEHILNSPKGELNYDFFEALENTYPNMIKLIDNLGNAEIKKLI
KVTGYMLVSKK

3D structure

PDB

4uci X-Ray Structure and Activities of an Essential Mononegavirales L-Protein Domain.

Chain

Resolution

2.21 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	H1766 H1798 C1802 C1805	H141 H173 C177 C180
BS02	SAM	A	S1668 T1670 G1696 E1697 A1699 G1700 N1701 L1720 D1725 D1755 A1756 D1779 A1780 E1781 F1782	S43 T45 G71 E72 A74 G75 N76 L95 D100 D130 A131 D154 A155 E156 F157
BS03	GTP	A	P1656 Q1658 R1662 S1668 S1669 T1670 K1673 K1843 E1848 K1991	P31 Q33 R37 S43 S44 T45 K48 K218 E223 K347
BS04	ADN	A	F1782 K1783 R1785 Y1818 H1819	F157 K158 R160 Y193 H194

External links

PDB	RCSB:4uci, PDBe:4uci, PDBj:4uci
PDBsum	4uci
PubMed	26549102
UniProt	Q91L20

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