Structure of PDB 4u9w Chain A

Receptor sequence
>4u9wA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
MEERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGL
EPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENS
SVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANS
TQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSCSYEILSRRTKF
3D structure
PDB4u9w The Molecular Basis for Histone H4- and H2A-Specific Amino-Terminal Acetylation by NatD.
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.257: N-terminal L-serine N(alpha)-acetyltransferase NatD.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y85 W90 D127 E129 Y136 Y138 E139 T174 Y211 Y70 W75 D112 E114 Y121 Y123 E124 T159 Y188
BS02 COA A M81 V140 Q141 L142 R147 R148 G150 G152 K153 N179 G181 F185 A189 M66 V125 Q126 L127 R132 R133 G135 G137 K138 N164 G166 F170 A174
Gene Ontology
Molecular Function
GO:0010485 histone H4 acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0043998 histone H2A acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4u9w, PDBe:4u9w, PDBj:4u9w
PDBsum4u9w
PubMed25619998
UniProtQ86UY6|NAA40_HUMAN N-alpha-acetyltransferase 40 (Gene Name=NAA40)

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