Structure of PDB 4u9a Chain A

Receptor sequence
>4u9aA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
HSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKL
AALKQQFDQEIKVMAKCQHENLVELLGFSLCLVYVYMPNGSLLDRLSCLD
GTPPLSWHMRCKIAQGAANGINFLHENHHIHRNIKSANILLDEAFTAKIS
DFGLATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPA
VDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQC
LHEKKNKRPDIKKVQQLLQEMT
3D structure
PDB4u9a IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N311 K313 A315 N316 D329 T351
Catalytic site (residue number reindexed from 1) N133 K135 A137 N138 D151 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A M192 E194 G195 V200 A211 K213 Y262 Y264 M265 A315 L318 S328 M27 E29 G30 V35 A46 K48 Y84 Y86 M87 A137 L140 S150
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4u9a, PDBe:4u9a, PDBj:4u9a
PDBsum4u9a
PubMed25201411
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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