Structure of PDB 4u5v Chain A

Receptor sequence

>4u5vA (length=426) Species: 10090 (Mus musculus) [Search protein sequence]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

4u5v Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.

Chain

Resolution

1.968 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RH2	A	N361 E396 W399 N403	N290 E325 W328 N332	MOAD: Kd=0.9mM PDBbind-CN: -logKd/Ki=3.05,Kd=0.9mM
BS02	RH2	A	E354 E396	E283 E325	MOAD: Kd=0.9mM PDBbind-CN: -logKd/Ki=3.05,Kd=0.9mM

External links

PDB	RCSB:4u5v, PDBe:4u5v, PDBj:4u5v
PDBsum	4u5v
PubMed	25899172
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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