Structure of PDB 4u5s Chain A

Receptor sequence

>4u5sA (length=426) Species: 10090 (Mus musculus) [Search protein sequence]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

4u5s Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.

Chain

Resolution

2.12 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	3D0	A	D280 G281 N319 V321 T322 W357 N361 E396 W399 N403	D209 G210 N248 V250 T251 W286 N290 E325 W328 N332	MOAD: Kd=3.9mM PDBbind-CN: -logKd/Ki=2.41,Kd=3.9mM
BS02	3D0	A	W142 N146 S149 G150 T155 Q181 W184 N188 D192 N228 W231 N235	W71 N75 S78 G79 T84 Q110 W113 N117 D121 N157 W160 N164	MOAD: Kd=3.9mM PDBbind-CN: -logKd/Ki=2.41,Kd=3.9mM

External links

PDB	RCSB:4u5s, PDBe:4u5s, PDBj:4u5s
PDBsum	4u5s
PubMed	25899172
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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