Structure of PDB 4u5o Chain A

Receptor sequence
>4u5oA (length=426) Species: 10090 (Mus musculus) [Search protein sequence]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
3D structure
PDB4u5o Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3D5 A V321 S360 N361 E396 W399 N403 V250 S289 N290 E325 W328 N332 MOAD: Kd=3.8mM
PDBbind-CN: -logKd/Ki=2.42,Kd=3.8mM
External links
PDB RCSB:4u5o, PDBe:4u5o, PDBj:4u5o
PDBsum4u5o
PubMed25899172
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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